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Paper Detail

Paper Title Some Enumeration Problems in the Duplication-Loss Model of Genome Rearrangement
Paper IdentifierTU2.R5.3
Authors Mladen Kovačević, Sanja Brdar, Vladimir Crnojević, University of Novi Sad, Serbia
Session Information Theory in Biology II
Location Saint Victor, Level 3
Session Time Tuesday, 09 July, 11:40 - 13:00
Presentation Time Tuesday, 09 July, 12:20 - 12:40
Manuscript  Click here to download the manuscript
Abstract Tandem-duplication-random-loss (TDRL) is an important genome rearrangement operation studied in evolutionary biology. This paper investigates some of the formal properties of TDRL operations on the symmetric group (the space of permutations over an n-set). In particular, the cardinality of ``balls'' of radius one in the TDRL metric, as well as the cardinality of the maximum intersection of two such balls, are determined. The corresponding problems for the so-called mirror (or palindromic) TDRL rearrangement operations are also solved. The results represent an initial step in the study of error correction and reconstruction problems in this context, and are of potential interest in DNA-based data storage applications.